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According to Tmz,

Tupac’s mother, Afeni Shakur, passes away Monday night due to possibly having a heart attack. Officials responded to a call which lead them to Afeni’s home, a upon arrival Afeni was found unresponsive.  She was transported to a hospital and later pronounced dead at 10:28 PM.  Before the passing of Afeni Shakur, she gave the green light on allowing a Tupac  biopic  “All Eyez on Me” which recently was finished up and will be released hopefully sometime this year.  The Marin County Sheriff are doing thorough investigate to determine the exact cause of Afeni’s death.